Frequently Asked Questions

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Non serious or non life threatening infection not treated by GP or hospitalStandalone
Antibiotic resistantStandalone or in addition and simultaneous to antibiotic therapy (ABT)
ABT failure for any other reasonStandalone
ABT allergic or adverse reactionStandalone
ABT side effects not toleratedStandalone
Serious or life threatening bacterial infectionIn addition and simultaneous to ABT. Standalone if ABT not available.
Viral infection without available drug treatment or after failure of antiviral drug therapy or if antiviral drug adverse reactions or side effects not toleratedStandalone
Vascular insufficiency or neurologically meditated vascular disease or condition affecting drug deliveryStandalone or in addition and simultaneous to ABT
First Aid and emergency disaster environmentStandalone if effect needs to be immediate and sterilizing solution not available or trauma damaged tissues cannot be physically contacted, or in addition and simultaneous to ABT

Each infection and treatment course will be unique.


Yes, the Output Current of the direct current (DC) SIS equipment can be programmed for the treatment of yeast and fungal infections.

No. The SIS equipment and technology are not appropriate for the treatment of parasite infections.

No. None of the side effects known to be caused by antibiotics and antiviral drugs have ever been reported.

Additionally, none of the side effects of antibiotics were reported by the electromedicine pioneer, American orthopedic surgeon Robert O Becker (1923-2008), nor by his research associates during their many hospital applications of silver-nylon cloth electrode iontophoresis or low intensity direct current (LIDC) treatments of infections and for tissue healing.

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No. Zappers, Rife machines, and bioresonance devices are all electromagnetic frequency generating devices.

The SIS technology for infection treatments utilizes low intensity (amperage) direct current (DC); it does not have an Output Current or Output Voltage frequency, as it is DC device technology.

The SIS technology and devices for infection treatments have no functional or therapeutic similarity to any frequency generating device.

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Typically (for a severe or acute infection or wound) with approaching ideal 24/7 continuous use, we recommend replacement of the (+)positive electrode every 12-48 hours, and replacement of the (-)(‘return’) electrode every 24-48 hours. These guidelines can be modified depending on anatomical location and other factors such as ambient temperature that will affect sweating.

Further information and instructions for application of the SIS electrodes are included in the operating manuals of the SIS machines, and on the Instructions For Use card included in each SIS electrode pack.




No, the SIS electrodes are not sticky. They need to be held onto the body using standard adhesive medical fixation tape or other types of physiotherapy or injury rehabilitation tape. Bandages or other emergency means can also be used if necessary.

Fixation tape is a generally available, non-prescription item from any chemist or pharmacy, and from our SHOP >




We do not give medical advice. Here is our general reply to this question for informational purposes only:

A ‘neoplasm’ is the medical term for what is commonly called a ‘malignancy’ or a cancerous growth. Neoplasms are occurrences that form over time as a result of many very complex and simultaneous processes.

The SIS equipment is not designed nor claimed to be effective when applied alone in the treatment of neoplasms. We explicitly disclaim that the SIS equipment can be applied alone to treat neoplasms or cancer disease.

Many neoplasms are known to be caused by infections, in addition to many other simultaneous co-factors; these include but are not limited to the more well known neoplasms that can develop in the liver, stomach and in the cervix of females. There is some research evidence that neoplasms in other organs of the body might also be co-factor caused by infections, especially by viruses. In so far as neoplasms have infectious agent co-factor causes, then the SIS equipment could be applied to treat these infections. However, as explained above, most neoplasms have multiple, simultaneous co-factor causes.

Higher intensities of direct current (DC) in the low milliampere range have also been reported to stimulate normal programmed cell death (‘apoptosis’) within neoplasms.

The SIS alternating current (AC) waveform generators can also have cellular normalizing and apoptosis effects.

Yes, but with caution and some restrictions. Refer to the WARNING below before attempting use. The SIS electrodes are only designed for use in the low microcurrent range and only with low voltages (maximum 5-10 Volts).

The SIS equipment and technology should not be compared to commonly available microcurrent stimulators, either electronically or therapeutically. These devices are not capable of the electronic requirements for silver iontophoresis or low intensity direct current (LIDC) therapeutics using silver-nylon cloth as electrochemical or electrical anode and cathode. The SIS equipment direct current (DC) devices have no output stimulation frequency. Most microcurrent stimulators are not DC devices: they are frequency emitting, pulsed waveform generating devices, similar to or actual alternating current (AC) devices.

For silver iontophoresis or low intensity direct current (LIDC) therapeutics using silver-nylon cloth electrodes acting as the (+)positive and (-)negative electrochemical or electrical anode and cathode for the release of silver cations (Ag+s) or for LIDC therapeutic effect, extremely stable ultra low amperage DC Output Current with nanoampere accuracy is required. This specification is beyond the capabilities of generally available microcurrent stimulators.

Additionally, the SIS electrostimulators are sophisticated realtime and statistical monitoring devices of the SIS silver-nylon cloth electrode↔skin contact. This function is also critical for silver iontophoresis or low intensity direct current (LIDC) therapeutics to occur over time at ultra low constant DC.



Yes, the M250 and M250MA SIS machines are ideal and easy to use for colloidal silver production. The SIS machine electrode cable can also be easily connected to widely available pure silver rods made specifically for colloidal silver production, using the set of Alligator Clip Cable Adaptors supplied with each SIS machine M250/M250MA. The SIS electrodes can also be used in place of silver rods, though the rate of silver ion release will be far slower.

The M250 and M250MA machines have an automatic voltage polarity reversal function, which is very useful for colloidal (ionic solution) silver production. Periodically, the voltage polarity reversal ‘cleans’ electrochemical debris from the surface of the silver rods or SIS electrodes that builds up during use. This function can be manually disabled if required.

No, they are entirely different. Please continue to the link below to read about the SIS technology for infection treatments, or first read the information below.


More information:

Delivery of ingested silver ions inside the body

‘Colloidal silver’ (ionic silver solution), though certainly of use for surface infections, has limitations for the treatment of internal infections. The human body is often imagined as something like a bathtub of water: if you drop a substance into it, it will homogeneously spread out and automatically go everywhere. The body has ‘compartments’ and ‘barriers’, at every order of anatomical scale, down to the sub-cellular level. Silver ions, as with molecules of any medication, do not automatically reach a target area of infection.

Cellular binding sites and internal anatomical pathways

For ingested colloidal silver solution or spray, there are millions or billions of molecular binding sites available for the (+)positively charged silver (cat)ions, starting high up in the gastrointestinal (GI) tract, before they can reach an infection. Internal pathways are very complex and long. For illustration, the chances of getting a therapeutic dose of silver ions to a kidney infection might be very small. The silver ions must get through the stomach, where they can bind to the stomach’s hydrochloric acid and be used up, then go through at least part of GI tract, and eventually find their way to the renal (kidney supplying) arteries and into the inner compartments of the infected kidney(s). If they are not somehow transported or pass out through the walls of the intestines into the bloodstream, they must further be transported out into the circulatory system via the portal venous system route collecting blood from the intestines back through the liver, then back into the heart, in and out of the lungs, then back into the heart again, and finally into systemic circulation.

Inflammation hinders medication delivery

Localized inflammation of the target tissues can limit the delivery of any medication in general circulation. When inflammatory chemicals are increased in localized areas of infection or injury, they can cause mechanical, obstructing changes inside and around the smallest blood vessels (arterioles). Additionally, these arterioles can also become (chronically) constricted under the control of the smallest motor nerve fibers of the autonomic nervous system, resulting in a reduced amount of any medicine delivered via the bloodstream to those target tissues.

SIS technology approach

The operation and effects of the SIS machines does not depend on blood flow. Operating on the basic physics of electric voltages, electric currents and conductivity, a microorganism-specific low intensity constant direct current (LIDC) is delivered via the shortest possible route, directly to the target infection.

To read about the SIS technology for infection treatments, please continue to the link below:


Yes. The SIS machines M250/M250MA have also been designed for small scale water treatment and purification purposes.

We have not yet conducted an independent laboratory test of water sterilization. We therefore disclaim that we imply or have any data to support or confirm the usefulness of the SIS machines for this purpose at this time. We intend to conduct the necessary assessment soon [target: 2022].

No. The SIS machines are not medical devices. The SIS machines are consumer health products, and the W and M series SIS machines are also devices for providing supplementary alerts and information to a healthcare professional for their decision-making in the course of their standard wound or infection management delivery, without giving any treatment.

The SIS machines share advanced technologies from the SIS development medical devices.

You can read more about the regulatory supply conditions of the SIS machines available on the Checkout page.

Yes. We provide full and ongoing support to the original purchase user of SIS equipment for its correct and optimal application. We will always communicate promptly and give as much help as necessary.

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Yes, with successful results that resulted in the recovery of the patients. In these cases, within major and regional hospitals, the SIS equipment was used at the insistence of the patients and/or their families, when standard treatments with intravenous and oral antibiotics were not giving the necessary results for these patients’ acute or emergency (antibiotic resistant) infections.

The SIS equipment has also been used within major and regional hospitals under the same circumstances, for the treatment of large, post-surgical, chronic and antibiotic resistant wound infections, and is confirmed to have saved leg amputations.

The hospital doctors were aware of and included the applications of the SIS equipment in their clinical notes. No adverse affects were reported by the hospital doctors or nurses.


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