Multirole Programmable AC Microcurrent



  • Second messengers are molecules that relay the first incoming signals received at receptors on the surface of a cell, to target molecules inside the cell. The incoming messengers that reach the cell are the extracellular signaling factors such as hormones and neurotransmitters that trigger the cell to take specific action(s).

  • A key feature of the second messenger signaling system is that it amplifies the incoming signals.

  • Precise targeting of electrical stimulation to either or both the important cyclic-AMP (cAMP) and cyclic-GMP (cGMP) second messengers.


  • Nociceptive type pain occurs when specialized sensory neurons called nociceptors, signal along axon nerve fibres to the brain that injury exists or that there is danger of injury to tissues of the body. The pain signals start from the inside-to-outside 'voltage-gated' ion channels through the walls of the nociceptor neurons.

  • Neuropathic type pain (neuropathy) is caused by damage to nerves themselves from trauma injury, surgery, disease or chemotherapy, so that they no longer function correctly.

Nociceptive type pain signals transmitted from peripheral sensory neurons to the spinal cord and brain

Neuropathic damaged nerve axon fibers (red) within a nerve bundle are therapeutic targets for cyclic-AMP mediated regeneration

  • Increasing cAMP activity directly affects the pain neuron.

    The targeted electrical stimulation does not cover up the natural pain generating process. The second messenger cAMP stimulation naturally decreases the overall activity and the specific electrical voltage across nociceptor neuron wall ion channels—reducing or stopping the transmission of pain signals.

    Favourably modulating cAMP also has strong regenerative effects on damaged peripheral nerve tissue (neuropathy).


  • Cyclic-A-M-P is produced within cells from the A-T-P molecule. A-T-P is the 'energy currency' of life and functions like a rechargeable battery, providing energy to cells to do work.

Cyclic-AMP (cAMP) second messenger activation and effects in response to injury

  • The cAMP molecular pathways relay and amplify the specific intracellular messages to carry out the healing processes for the injury. Supporting research>

    Programmable to precisely target and modulate up or down the production and utilization of the cAMP second messenger molecule and activation pathway.


  • The cyclic-GMP (cGMP) second messenger pathway relays and amplifies signals that increase the mobilization of energy resources by up-regulating glucose metabolism in muscles around the injury. The increase in available energy accelerates injury healing. cGMP also enhances cell migration including stem cells to injured tissues such as wounds, and has angiogenesis (regeneration of blood vessel) stimulating effects. Supporting research>

    Programmable to precisely target and modulate up or down the production and utilization of the cGMP second messenger molecule and activation pathway.


    The beneficial effects on pain and injury from increasing cAMP and cGMP activity have been extensively studied with chemical interventions. The SIS technology is the first programmable, targeted electromedical approach that can achieve these results. Supporting research>


  • The SIS technology has been developed from special cooperation between American Physiatrist (pain and injury rehabilitation specialist physician) and scientist, Dr James Woessner MD PhD, and the Electromedicine Clinic in Melbourne, Australia. Dr Woessner pioneered and performed around 4000 non-invasive electrical nerve block treatments, which he recognized were simultaneously actually repairing damaged nerves fibres, probably via cAMP activation. Vita of Dr James Woessner>

    The SIS AC waveform stimulation technology is the result of data based development in parallel with laboratory equipment validation and clinical testing.

    The SIS AC waveform stimulation device has been designed for use by both clinicians and at home.


  • The healing process in response to an injury is fantastically complex, involving millions of cells. Each cell performs a unique and specialized function in the work to repair and regenerate the injured tissues, in moment-by-moment constantly changing coordination with every other cell.

    We cannot know what each cell involved in the healing process is doing at any time: trillions of chemical reactions happen in the body every second—most remain unknown to medical science. This makes appropriate electrical stimulation at any point in time very hard to determine.

  • No two injuries are the same. Every injury, even of the same anatomical structure, is a unique occurrence in each individual, requiring their body's precisely coordinated, unique healing response.

    Most electrotherapy devices for injury and pain treatments, transmit waveforms and frequencies into the body, in a non-targeted, 'blanket' bombardment of electrical stimulation (energy). Some cellular metabolic activities can be temporarily enhanced as a result, while other cellular processess can be negatively interfered with or completely inhibited.

    The SIS second messenger stimulation technology solves these electrotherapy challenges by directly targeting and boosting what the body is already doing via precise stimulation of the second messenger signaling system that accelerates healing and regeneration of the damaged tissues.


  • Pain neuron (nociceptor) blockade—cAMP directly affects the pain neuron wall voltage-gated ion channels, so that neuropathic pain signals reduce or stop.

  • Relays and greatly amplifies the first incoming extracellular messages to begin and continue the metabolic activity for healing—including genetic expression.

  • Increases neuron and axon (sensing and movement signal conductors) survival and regeneration following injury.

  • Immune and non immune system anti-inflammatory effects, giving immediate and long term injured tissue protection.

  • Circulation enhancement—induces and enhances localized vascular relaxation.

  • Reduces muscle tension and exerts central nervous system antispastic actions after injury.

  • Enhances the effects of functional stimulation and regeneration of muscles and nerves following injury.

  • Enhances angiogenesis in injured tissues (regeneration of new blood vessels).

  • Increases mobilization of energy resources via the carbohydrate metabolism pathway and accelerates tissue healing.


  • Enhanced and faster injury healing. Targeted bio-signaling stimulation of intracellular 'second messenger' molecule pathways: cyclic-A-M-P and cyclic-G-M-P that relay and amplify the messages for metabolic activity and healing.

  • Neuropathic pain blocking. Decreases the overall activity and the 'action potential' electrical voltage of pain nerve cell 'voltage-gated' ion channels, reducing or stopping the transmission of pain signals.

  • Increased nerve cell (neuron) and axon survival and regeneration after injury. Prevention of future neuropathic pain and loss of function.

  • Anti-inflammatory. Modulates both immune and non immune system inflammatory processes—protects injured tissues from chronic degradation.

  • Enhances circulation. Relaxes localized small blood vessels (vasodilation).

  • Reduces muscle tension. Enhances function and regeneration of muscles and nerves following injury.

  • Increases localized carbohydrate metabolism. Increased energy accelerates tissue healing.

  • Non-invasive and no drug side effects. For home and clinic use.

  • International Patent Application Pending device & technology.