WM-Cyclic-AMP Stimulator


  • Nociceptive type pain occurs when pain nerve cells (specialized sensory neurons called nociceptors) are signalling along nerve fibres to the brain that injury exists or that there is danger of injury to tissues of the body.

Pain Signal Transmitted from the Voltage-Gated Ion Channels Through the Pain Nerve Cell Walls

  • The outgoing pain signals start from the inside-to-outside voltage-gated ion channels through the nociceptor cell walls.

Voltage Gated Ion Channels Through the Walls of Nociceptor Pain Nerve Cells

  • Neuropathic type pain (neuropathy) is caused by damage to nerves themselves from trauma injury, surgery, disease or chemotherapy, so that they do not function correctly.

    The WMcAMP Stimulator does not 'cover-up' the natural pain-generating process. The WMcAMP Stimulator directly modulates the cAMP signal transduction pathway, with the result of decreasing the overall activity and the specific electrical voltage across nociceptor wall ion channels—reducing or stopping the transmission of pain signals. Supporting research>

    In addition, favourably modulating cAMP has strong regenerative effects on damaged peripheral nerve tissue (neuropathy), which has been extensively studied via chemical-based cAMP intervention. The WMcAMP Stimulator is the first dedicated electromedical approach that can achieve this result. Supporting research>


  • Cyclic-A-M-P is produced within cells from the A-T-P molecule. A-T-P is called the 'energy currency' of life, it functions like a rechargeable battery, and is the energy source that all cells need in order to do anything within the human body. In response to injury, A-T-P (ATP) is converted in a repeating cycle into cyclic-A-M-P (cAMP); the cAMP molecules then relay the specific messages to carry out the healing processes for the injury.

    The WMcAMP Stimulator provides precisely targeted electromagnetic signals that directly increase production of the cAMP molecule, and then directly increase the utilization of the cAMP messenger pathways, activated in specific responses to the injury.

Cyclic AMP (cAMP) Second Messenger Activation and Effects in Response to Injury

  • The WMcAMP Stimulator generates a repeating, timed, complex stimulation cycle that enhances and is in sync with the natural cAMP messenger pathway events inside the cells of the body.

    The powerful and beneficial effects of enhancing the cAMP messenger pathways for pain and injured tissue healing and regeneration, are well-studied biological and medical science. Supporting research>


  • The Cyclic AMP (WMcAMP) Stimulator has been developed from special cooperation between American Physiatrist (pain and injury rehabilitation specialist physician) and Scientist, Doctor James Woessner MD PhD, and the Electromedicine Clinic in Melbourne, Australia. Dr. Woessner has pioneered and performed around 4000 non-invasive electrical nerve block treatments, which he recognized were simultaneously actually repairing damaged pain nerves via cAMP activation. Vita of Dr James Woessner MD PhD>

Damaged Nerve Fibers (red) Within a Nerve Bundle: Targets for cAMP Mediated Regeneration

  • The WMcAMP Stimulator is the result of data-based development, in parallel with laboratory equipment validation and clinical testing.

    The WMcAMP Stimulator has been designed for use by both clinicians and at home.


  • The healing process in response to an injury is fantastically complex, involving millions of cells. Each cell performs a unique and specialized function in the effort to repair and regenerate the injured tissues, in moment-by-moment constantly changing coordination with every other cell.

    We do not know what each cell involved in the healing process is doing moment-by-moment; trillions of chemical reactions happen in the body every second—most remain unknown to medical science.

  • No two injuries are the same; every injury, even of the same anatomical structure, is a unique occurrence in each individual, requiring their body's precisely coordinated, unique healing response.

    Most electrotherapy devices for injury and pain treatments, transmit waveforms and frequencies into the body, in a non-targeted, 'blanket' bombardment of electrical stimulation (energy). Some cellular metabolic activities can be temporarily enhanced as a result, while at the same time, others can be negatively interfered with or completely inhibited.

    The WMcAMP Stimulator solves these electrotherapy challenges by directly targeting and boosting what the body is already doing to heal and regenerate the damaged tissues (the injury).


  • Pain neuron (nociceptor) blockade—cAMP directly affects the the pain nerve cell (neuron) wall voltage-gated ion channels, so that neuropathic pain signals reduce or stop.

  • Relays the messages to begin and continue the metabolic activity for healing—including genetic expression.

  • Increases neuron and tissue survival and regeneration following injury.

  • Controls the ability of nerve cell axons (sensing and movement signal conductors) to regenerate after injury.

  • Immune and non-immune system anti-inflammatory effects, giving immediate and long-term injured tissue protection.

  • Circulation enhancement—by blocking the signalling of the very small diameter (C fiber type) motor nerves, resulting in vasodilation ('holding open') of the localized very small blood vessels (arterioles).

  • Reduces muscle tension, and exerts central nervous system antispastic actions after injury.

  • Functional stimulation and regeneration of muscles and nerves.

  • Enhances whole brain and brain cell connection (synapse) plasticity following injury.


  • Enhanced and faster injury healing. Precision, targeted signalling stimulation increases the production and utilization of intracellular Cyclic-A-M-P molecules—that activate and relay the messages for metabolic activity for healing, including gene expression.

  • Neuropathic pain blocking. Decreases the overall activity, and the 'action potential' electrical voltage, of pain nerve cell voltage-gated ion channels—reducing or stopping the transmission of pain signals.

  • Increased nerve cell (neuron) and axon survival and regeneration after injury (neuroregeneration). Prevention of future neuropathic pain and loss of function.

  • Anti-inflammatory. Favorably modulates both immune and non-immune system inflammatory processes—protects injured tissues from chronic degradation.

  • Enhances circulation.

  • Reduces muscle tension. Enhances function and regeneration of muscles following injury.

  • Non-invasive and no drug side effects. For home and clinic use.

  • Pre-set mode in PACSTIM model. Also available as a pre-set stimulation mode in the programmable AC microcurrent stimulator (PACSTIM) model SIS machine.

  • Robust construction including casing and connectors. Medical device standard radiated emissions certified. Each unit is a precision electronics instrument. 5 year warranty.

  • Patent pending device & technology.