INJURED TISSUE REGENERATION

MODIFICATION OF CELLS FOR TISSUE HEALING AND REGENERATION

  • The SIS machine W250 model and SIS electrodes when operated in REGEN operational mode, completely and accurately fulfill the specifications of the electrical stimulation method for tissue healing and regeneration pioneered by American orthopedic surgeon, Robert O Becker (1923-2008).

    Stimulation of fibroblast (FB) cells in the wound to self-modify to have tissue regeneration abilities resembling stem cell potentials.



USA Patent Documentation


HOW IT WORKS

  • The silver iontophoresis and low intensity (amperage) direct current (LIDC) of the SIS machine W250 model stimulates the dedifferentiation and transdifferentiation (self-modification) of mature FB cells in the location of the damaged tissue—the dedicated cells that make the structural, fibrous extracellular matrix of the body.

  • This process provides a new population of myofibroblast cells, and other modified cells types with tissue regeneration abilities resembling pluripotent stem cell potentials, directly within the damaged tissue. Supporting research>

  • The newly modified cells become available to remodel existing tissues and form new tissues to an extent not normally possible in the human body.


SURFACE WOUND TREATMENT

  • When applied to surface wounds, the newly modified FB cells are available to remodel wound site tissues during the proliferative and remodeling phases of wound healing.

  • The electrical stimulation can also result in less scar tissue formation, with faster and better wound healing.

  • SIS machine W250 model function: realtime, self-adaptive scaling of stimulation voltage to SIS electrode size and damaged tissue properties within the low intensity direct microcurrent range for tissue regeneration.


INTERNAL FIBROTIC, SCAR AND INJURED TISSUE TREATMENT

  • Based on extensive clinical research and results—included first of its kind radiographically confirmed chronic lung scar tissue reversal—the SIS machine W250 model applied in REGEN operational mode, utilizes data-based calculations to determine the appropriately scaled electrical stimulation for any internal tissue target.

    SIS machine W250 model function: user-programmable SIS (+)positive electrode size for the individual application and target tissue size; self-adaptive scaling of low intensity direct microcurrent to the programmed (+)positive electrode size for tissue regeneration.



Radiology Documentation of Chronic Lung Scarring Reversal


AI POWERED WOUND HEALING

  • Infection treatment. microenvironment-to-microorganism-type-specific, low intensity direct current. Effective for bacterial, viral and antibiotic resistant superbug infections.

  • Bioelectric healing. Realtime, self adaptive supplementation or replacement of the bioelectric controller of wound healing—the wound-generated electric field; boosts the natural 'current of injury'.

  • Accelerated healing. Targeted bio-signaling stimulation of intracellular 'second messenger' molecule pathways: cyclic-A-M-P and cyclic-G-M-P that relay and amplify the messages for metabolic activity and healing.

  • Better healing, less scar tissue. Stimulates the self-modification of fibroblast cells in the wound to have tissue regeneration abilities resembling stem cell potentials.

  • Reduces pain. Effects on: inflammatory mast cells, cross-talk between pain signaling nerve fibers, nociceptor ion channels that detect harmful stimuli, reducing the transmission of pain signals.

  • SIS electrodes do not contact wound. No discomfort or disturbance of new (granulation) tissue growth.

  • No drug side effects or risks. Quick and easy to apply. For home and in clinic use.

  • Artificial Intelligence (AI) machine learning. Repeated electrical stimulation optimization for each individual wound. Device learns how to heal each specific wound and continuously improves its function.

  • International Patent Application Pending device & technology.

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