Low Voltage Cranial Electrical Stimulation

SYSTEMIC RELAXATION

MODULATION OF ADRENAL STRESS AND STEROID HORMONES

BENEFICIAL EFFECTS ON DEPRESSION, MOOD, ANXIETY AND INSOMNIA

CENTRAL NERVOUS SYSTEM PAIN REGULATION

REDUCED MUSCLE SPASTICITY

BETA BRAINWAVE AUGMENTATION FOR INCREASED ALERTNESS

TREATMENT OF SUBSTANCE ADDICTION AND WITHDRAWAL SYMPTOMS

  • The SIS AC waveform generator is fully programmable to operate as a technological advance and development on the Modulated Electric Energy Stimulators and their derivatives, patented in the USA by Dr. Saul Liss, which have been used 1000s of times by physicians in the USA and worldwide. Patents of Dr. Saul Liss>


  • From our biomedical engineering design and stimulation technological advances, compared to the earlier Liss devices (designed 1980-1990), the device delivers a higher precision stimulation waveform that achieves powerful effects at very low voltages.

    The SIS AC waveform generator is the first waveform generating cranial electrical stimulation (CES) device that achieves comparative or greater, known CES therapeutic effects, with extremely low applied stimulation electrical voltages (1000× lower) even in the low milli-volt range.



HOW IT WORKS: NEUROTRANSMITTERS

  • Neurotransmitters are a type of the body’s chemical messengers. They are the molecules used by the nervous system to transmit messages between its nerve cells (‘neurons’), and from neurons to muscle cells. Neurotransmitters influence neurons in excitatory, inhibitory and modulatory ways.


  • Neurotransmitters control and influence many major body functions including breathing, heartbeat, movement, emotional response, concentration, mood, feelings of pleasure and satisfaction, and pain signal transmission and perception.



Neuron Neurotransmitter Junction

  • The SIS AC waveform generator influences nerve activity by delivering electrical energy, in the form of specific signal frequencies, to the brain. The electrical energy penetrates into the brain via a specially, amplitude ‘modulated’ waveform, which acts as a ‘carrier’ of the active signal stimulation frequencies. To achieve this carrier function, the modulated waveform is specially designed to utilize to advantage the composite electrical properties (impedance) of the bones of the skull, to transmit the stimulation electrical energy into the brain.

    The published CES and Liss Modulated Electric Energy Stimulator research shows strong, beneficial alteration of the levels of neurotransmitters: Serotonin—related to mood, sexual function, appetite, sleep, memory, learning and some social behavior, Melatonin—related to sleep-wake cycles, beta-Endorphin & GABA—related to transmission and sensation of pain, and on Cortisol and DHEA—adrenal stress and steroid hormones, measured in the cerebral spinal fluid in the brain and spinal cord, and in the bloodstream.


HOW IT WORKS: BRAINWAVE AUGMENTATION

  • Also capable of brainwave augmentation, the SIS AC waveform generator can be programmed to deliver stimulation frequencies that are in the Beta brainwave band.

    Beta brainwaves are associated with the normal, waking state of consciousness of focused activity, decision-making and general alertness.



Frequency Bands of Brain Waves


SUPPORTING RESERARCH & HEALTH REGULATIONS

  • Modulated electric energy stimulation—under the category of cranial electrical stimulation (CES)—is backed in the USA by 30+ peer-reviewed published studies, around 20 patents, and by the USA Food and Drug Administration (FDA) and Health Canada marketing clearance for the treatment of anxiety, depression, and insomnia disorders.

    Applications are drug free and no negative effects or major contraindications have been reported from the use of amplitude modulated frequency CES.



DEVICE DEVELOPMENT

  • Neurosurgeon, C. Norman Shealy used the first implantable neuromodulation electrotherapy device for the treatment of chronic pain in 1967. Later on, he found that the same effects could be achieved via non-invasive electrical stimulation.

  • The original Modulated Electric Energy Stimulator technology was gradually developed and patented beginning in the 1980s by scientist and medical engineer, Dr Saul Liss (-2006) together with Shealy.

  • "Modulated Electric Energy Stimulators are devices which . . . have a beneficial clinical effect on the human in reducing pain, and symptoms of depression, anxiety, and insomnia . . . to reduce spasticity, enhance alertness and increase attention span in the normal and increase the cognitive performance of neuronally deficient children." [Liss 1999]

  • The technology was developed from "analyzing the physics characteristics of the body and match[ing] the dynamic electrical 'impedance' [part of which is electrical resistance] of the body with a stimulation pattern which the body could then convert into an internal signal that it could use constructively to help the body help itself." [Liss 1999]

  • Up until now, most currently available, both alternating current (AC waveform) and direct current (DC), cranial electrical stimulation (CES) devices have used relatively high stimulation voltages applied to the brain—typically 20-30 volts. Most of this delivered electrical energy is unnecessary to achieve strong therapeutic effects; Dr Liss knew this and orignally developed much lower voltage devices; he only added the higher voltages in order to convince people that they worked as they could then feel the stimulation.

  • From our independent biomedical engineering R&D, in parallel with the extensive experiences from a dedicated electromedicine clinical practice and research lab, we have developed on the Liss and other existing waveform cranial electrical stimulation (CES) technologies, to advance the field of CES and produce the world’s first low voltage transcranial stimulator.

    • The SIS AC waveform generator maintains or enhances the established therapeutic effects of CES, while very dramatically reducing overall user exposure to electrical energy.


LOW VOLTAGE CRANIAL ELECTRICAL STIMULATION

  • Enhancing Brain Neuromodulation. Gentle beneficial effects on levels of neurotransmitters including Serotonin—related to mood, sexual function, appetite, sleep, memory, learning and some social behavior, and Melatonin—related to sleep-wake cycles, and on Cortisol and DHEA—adrenal stress and steroid hormones.

  • Brainwave Augmentation. Stimulation frequencies in the Beta brainwave band of the normal waking state of focused activity, decision-making and general alertness.

  • Central Pain Modulation. Beneficial effects on levels of neurotransmitters, Beta-Endorphin and GABA—related to transmission of pain signals and the body’s natural pain relief mechanisms.

  • Low Voltage Cranial Electrotherapy. Far lower (1000×) milli-volt range stimulation achieves comparative or greater therapeutic effects than high voltage devices (typically: 20-30 volts). Safer, wider application, less risks of side effects, no unnecessary optic nerve stimulation or dizziness. Easier and more comfortable application—no wet sponge pads, tingling or burning under pads; less chance of skin irritation.

  • Advanced Cranial Electrical Stimulation (CES). Technological development of the Liss Cranial Modulated Electric Energy Stimulator USA patents. Higher precision, more targeted, state of the art digital electronics generated and amplitude modulated waveforms. Auto-regulating stimulation intensity maintains therapeutic effect at real world, changing electrical circuit resistances when attached to the body. User programmable.

  • International Patent Application Pending device & technology.

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