• The W200 constantly monitors the electric field generated by the individual wound. The wound-generated electric field is the key, bioelectric controller of wound healing—the 'current of injury'.

  • The W200 self-adapts to the individual wound. The W200 gives real-time, 'smart' electrical stimulation that precisely supplements or replaces the wound-generated electric field.

  • The W200 treats and prevents infection with silver ion delivery direct to the wound bed. Effective for antibiotic-resistant superbugs.

  • The W200 stimulates fibroblast cells in the wound to self-modify to have some of the regrowth abilities of stem cells.

    The SIS machine W200 electro-stimulation (electrotherapy) technology integrates key wound healing and tissue regeneration medical science that has remained in the research field until now.

  • The SIS machine W200 model can be applied to all kinds of wounds:

    - Non-healing chronic wounds

    - Diabetic Leg and Foot ulcers

    - Infected wounds

    - Post-Surgical wounds (infected)

    - Trauma wounds (protection, sterilization)

    - Venous stasis ulcers

    - Arterial ulcers

    - Pressure ulcers (“bedsores”)

    - Necrotizing soft tissue infections


  • Electro-physiological and bioelectric wound healing dynamics are well established phenomenon:

  • The skin acts as an electrical battery. As a result of the normal, bidirectional 'pumping' of chemical ions through the skin layers, a constant electrical potential (voltage) of 10/20-50/70millivolts is permanently maintained through the skin, termed the transepidermal or transepithelial potential difference (TEP).

Transepidermal Potential Difference

  • Intact skin has relatively high electrical impedence to the TEP. When skin layers are damaged or destroyed in any kind of wound, their electrical impedence to the TEP ‘skin battery’ immediately drops or disappears. The resulting TEP-generated electric field is electrically negative at the wound edges relative to the deeper tissues.

  • Many key cells involved in the healing response are sensitive to the TEP-generated electric field. The TEP electric field is the informational signal to these cells to move towards the wound surface, as well as for their differentiation, division and proliferation. These electric field-sensitive cells include osteoblasts, osteoclasts, keratinocytes, neural crest cells, endothelial cells, epithelial cells, chondrocytes, granulocytes, fibroblasts and leukocytes.

    The variable TEP voltage gradient through the wound is the key, local bioelectric controller of wound healing.


Bioelectric Wound Healing

W200 Stimulation Cycle


  • Treatment of present infection and prevention of infection. Broad antimicrobial action from direct constant-current silver ion (Ag+) delivery to the wound bed.

    The non-wound-contacting SIS electrode positioning for surface wounds, eliminates all physical disturbance of the wound, and any interference with granulation tissue formation—as with most wound dressings.


  • Bioelectrically matching, self-adaptive supplementation or replacement of the wound-generated electric field.

    The SIS machine W200 model's approach of real-time, self-adaptive wound-generated electric field supplementation or replacement, has major advantages. Most wound healing electrotherapy devices use non-adaptive, 'blanket' frequency-based electrical stimulation, non-specific to the individual wound.


  • Electrical stimulation of tissue healing and regeneration. Stimulates fibroblast cells in the wound to self-modify with some of the regrowth abilities of stem cells.

    These newly modified cells become available to remodel and form new tissues during the proliferative and remodeling Phases of wound healing to an extent not normally possible in the human body.


  • Bioelectric and electro-stimulation parameter data readout. Continuous electrical resistance monitoring at the edge of a superficial wound or automatically calibrated through a deeper wound, provides an accurate assessment of the rate and stage of individual wound healing.

    The SIS W200 wound electrical resistance monitoring has the advantage that it can be performed without having to remove dressings and without visual examination. These real-time measurements also give clinically useful information about the moisture of the wound bed that is also an established co-factor in speed of wound healing.


  • Treatment and prevention of infection. Direct constant-current silver ion delivery to the wound. Effective for antibiotic-resistant superbug infections.

  • Faster wound healing. Real-time, self-adaptive supplementation or replacement of the key bioelectric controller of wound healing—the wound-generated electric field; boosts the natural 'current of injury'.

  • Reduces pain.

  • Better healing, less scar tissue. Stimulates 'fibroblast' type cells in the wound to self-modify to have regrowth abilities of stem cells for tissue regeneration.

  • SIS electrodes do not contact wound. No discomfort or disturbance of new ('granulation') tissue growth.

  • For all types of surface wounds, skin ulcers, and internal fibrotic scar tissue.

  • No drug side effects or risks.

  • Quick and easy to apply.