WM Cyclic AMP Stimulator

$2,230.00 NZD

Description

– Pain Blocking, Injury Treatment, Electrotherapy, Neuropathy, Neuropathic, Regeneration, Healing, Inflammation –

– Pain Blocking, Injury Treatment, Electrotherapy, Neuropathy, Neuropathic, Regeneration, Healing, Inflammation 

Woessner-Malter Cyclic AMP Stimulator (WMcAMP)

DEVICE FUNCTION

The WMcAMP Stimulator is the first electrotherapy device of its kind in the world. The WMcAMP Stimulator is the result of data-based development, in parallel with laboratory equipment validation and clinical testing.

Bioelectric waveforms are generated in a timed stimulation pattern, which have been tested and programmed to stimulate the production and utilization of the cellular ‘second messenger’, Cyclic AMP (3′,5′-cyclic adenosine monophosphate.

The WMcAMP Stimulator has been designed for use by both clinicians and non healthcare professionals.

Established effects of cAMP stimulation include:

  • Pain reducing (blocking)
  • Increased nerve tissue survival and regeneration after injury
  • Immune and non-immune system anti-inflammatory
  • Local circulation enhancement
  • Functional stimulation and regeneration of muscles and nerves
  • Injured tissue protection
  • Cellular ‘apoptosis’ (programmed cell death) normalization

We describe the WMcAMP Stimulator as a functional normalizer.

LEARN MORE >

SUPPORTING RESEARCH >

– Pain Blocking, Injury Treatment, Electrotherapy, Neuropathy, Neuropathic, Regeneration, Healing, Inflammation –

NEVER TISSUE REGENERATION

Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.

Neuronal Cyclic AMP Controls the Developmental Loss in Ability of Axons to Regenerate.

Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury.

Cyclic AMP Signaling: A Molecular Determinant of Peripheral Nerve Regeneration.

Differential Effects of cAMP in Neurons and Astrocytes.

 

PAIN REDUCING

Blocking Out the Pain: Electric nerve block treatments for sciatic neuritis.

Inhibition of the cyclic adenosine monophosphate pathway attenuates neuropathic pain and reduces phosphorylation of cyclic adenosine monophosphate response element-binding in the spinal cord after partial sciatic nerve ligation in rats.

Dose-related antiallodynic effects of cyclic AMP response element-binding protein-antisense oligonucleotide in the spared nerve injury model of neuropathic pain.

Increased phosphorylation of cyclic AMP response element-binding protein (CREB) in the superficial dorsal horn neurons following partial sciatic nerve ligation.

Involvement of the cyclic AMP system in the switch from tolerance into supersensitivity to the antinociceptive effect of the opioid sufentanil.

Intrathecal administration of cyclic AMP response element-binding protein-antisense oligonucleotide attenuates neuropathic pain after peripheral nerve injury and decreases the expression of N-Methyl-D-Aspartic receptors in mice.

Cyclic AMP and cyclic GMP quantitation in pulp and periapical lesions and their correlation with pain.

Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model.

 

ANTI-INFLAMMATORY 

The effects of increased cAMP content on inflammation, oxidative stress and PDE4 transcripts during Brucella melitensis infection.

Electrical stimulation enhances cell migration and integrative repair in the meniscus.

Mitigation of chlorine lung injury by increasing cyclic AMP levels.

Activation of Cyclic Adenosine Monophosphate–Dependent Protein Kinase A Signaling Prevents Liver Ischemia/Reperfusion Injury in Mice.

Influence of ischemic injury on vein graft remodeling: Role of cyclic adenosine monophosphate second messenger pathway in enhanced vein graft preservation.

 

MUSCLE TISSUE INJURY REGENERATION

CREB is activated by muscle injury and promotes muscle regeneration.

Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase. 

cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration.

 

CELLULAR APOPTOSIS NORMALIZATION

The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment.

The role of cAMP in regulating tumour cell growth.

Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts.

Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2.

Cholera-toxin-enhanced growth of human breast cancer cell lines in vitro and in vivo: interaction with estrogen.

The cAMP signaling pathway as a therapeutic target in lymphoid malignancies.

Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma.

The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment.

Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells.

 

What does Cyclic AMP do?

 

Additional information

Weight 1.5 kg
WHAT'S INCLUDED

WM Cyclic AMP (3',5'-cyclic adenosine monophosphate) second messenger production and utilization electro-stimulator:

Single channel output
Output Voltage adjustable
IP54 rated casing with shockproof silicone cover
IP68 rated 1m electrode harness
Protective carry case
Electrode pack:
2 × small round silver-nylon SIS Electrode Pack (total 8 electrodes)
2 × pack of 4 round 4.8cm [1"] Hydrogel (TENS) electrodes (total 8 electrodes)
2 × dual connector large butterfly hydrogel (TENS) electrodes (total 2 electrodes)
Fixomull® Stretch Tape Box 10cm × 10m
3 Years Electronics Warranty
Full user support
Access to Practitioner Forum for clinicians

SPECIFICATIONS

– Power Source: 4 × AA.
– Maximum Input Voltage: 3.5-5V.
– Maximum Output Voltage: 2V.
– Maximum Internal Frequency: 8Mhz.
– Maximum Input Current: 100mA.
– Maximum Output Current: 10mA.
– Dimensions (cm)—with detachable shockproof cover/[enclosure only]: 105/[96](W), 48(35)(D), 153.9/[145](H).
– Weight (g) without batteries—with detachable shockproof cover/[enclosure only]: 303/[156].

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