ADVANCED wound healing

The SIS machine W200 is the world’s first real-time, self-adaptive wound healing electro-stimulator.
The W200 constantly monitors the electric field generated by the individual wound. The wound-generated electric field is the key, bioelectric controller of wound healing—the 'current of injury'.

The W200 self-adapts to the individual wound. The W200 gives real-time, smart electrical stimulation that precisely supplements or replaces the wound-generated electric field.

The W200 treats and prevents infection with silver ion delivery direct to the wound. Effective for antibiotic-resistant superbugs.

The W200 stimulates fibroblast cells in the wound to self-modify with regrowth abilities of stem cells.
The SIS machine W200 electro-stimulation (electrotherapy) technology integrates key wound healing and tissue regeneration medical science that has remained in the research field until now.

The SIS machine W200 model can be applied to all kinds of wounds:

- Non-healing chronic wounds

- Diabetic Leg and Foot ulcers

- Infected wounds

- Post-Surgical wounds (infected)

- Trauma wounds (protection, sterilization)

- Venous stasis ulcers

- Arterial ulcers

- Pressure ulcers (“bedsores”)

- Necrotizing soft tissue infections

stimulation complex


Electro-physiological and bioelectric wound healing dynamics are well studied phenomenon.
The skin is an efficient electrical battery that normally and permanently ‘stores’ a voltage, as a result of the normal, bidirectional pumping of ions through the skin layers. A constant electrical potential of 10(20)-50(70)millivolts is maintained across the skin, termed the transepidermal or transepithelial potential difference (TEP).
Intact skin has relatively high electrical impedence to the TEP. When skin layers are damaged or destroyed in any kind of wound, their electrical impedence to the TEP ‘skin battery’ immediately drops or disappears. The resulting TEP-generated electric field is electrically negative at the wound edges relative to the deeper tissues.

Many key cells involved in the healing response have membrane receptors sensitive to the TEP-generated electric field. The TEP electric field is the informational signal to these cells to migrate outwards to the wound surface; as well as for their differentiation, division and proliferation. These electric field-sensitive cells include osteoblasts, osteoclasts, keratinocytes, neural crest cells, endothelial cells, epithelial cells, chondrocytes, granulocytes, fibroblasts and leukocytes.
The variable TEP voltage gradient through the wound is the key, local controller of wound healing.

transepidermal potential difference

stimulation cycle

Stage 1
Treatment of present infection and prevention of infection. Broad antimicrobial action from direct constant-current silver ion (Ag+) delivery to the wound bed.
Additionally, the non-wound-contacting SIS electrode positioning for surface wounds, eliminates all physical disturbance of the wound, and any interference with granulation tissue formation—as with most wound dressings.

Stage 2
Bioelectrically matching, self-adaptive supplementation or replacement of the wound-generated electric field.
The SIS machine W200 model's approach of real-time, self-adaptive wound-generated electric field supplementation or replacement, has major advantages. Most wound healing electrotherapy devices use non-adaptive, ‘blanket’ frequency-based electrical stimulation, which is non-specific to the individual wound.

Stage 3
Electrical stimulation of tissue healing and regeneration. Stimulates fibroblast cells in the wound to self-modify with the regrowth abilities of stem cells.
These newly modified cells become available to remodel and form new tissues during the Proliferative and Remodeling Phases of wound healing to an extent not normally possible in the human body.

Wound Monitoring
Bioelectric and electro-stimulation parameter data readout. Continuous electrical monitoring through deeper wound beds or automatically calibrated at the edges of superficial wounds, provides an accurate assessment of the rate and stage of healing of the wound, with the formation of initial 'granulation tissue' and as the skin layers are rebuilt.
The SIS W200 wound healing electrical resistance monitoring has the advantage that it can be performed without having to remove dressings and without visual examination. These real-time measurements also give clinically useful information about the moisture of the wound bed that is also an established co-factor in speed of wound healing.


Advanced Wound Electrotherapy